Job Purpose

This ambitious project is funded for 5 years by an MRC Programme Grant and is focussed on investigating how regulation of the mRNA translation machinery influences initiation of hepatocellular carcinoma. We are looking to recruit a structural or cellular biologist to lead the ultrastructural arm of the project using cryo-electron tomography (cryo-ET) combined with cryogenic correlated light and electron microscopy (cryo-CLEM) and cryo-focused ion beam (cryo-FIB) milling. This programme will involve state-of-the-art imaging approaches to visualise molecular details of the intricate relationships between the mRNA translation and membrane trafficking machineries. The successful candidate will be trained in how to apply cryo-ET coupled with fluorescence to map key functional proteins and contribute to the study of how regulation of the mRNA translation machinery influences initiation of hepatocellular carcinoma. The ideal candidate will have experienc...